Reactivos Silenciamiento Génico -ON-TARGETplus siRNA Set of 4 - Mouse
Disponible
Guaranteed gene silencing and patented modifications to reduce off-targets; available as pre-designed ON-TARGETplus SMARTpool and siRNA reagents for human, mouse or rat.
Envase | 5 nmol |
---|---|
Aplicaciones | Silenciamiento génico |
Categoría de Producto | siRNA ON-TARGET plus |
Temperatura Envío | Ambiente |
Temperatura Almacenaje | Refrigerado 4º |
Formato Especial | Grupo de 4 |
Disponibilidad | Bajo pedido |
Especie/Huesped | Ratón |
Especificaciones | Highlights Off-targets reduced by up to 90% compared to unmodified siRNA Guaranteed silencing by SMARTpool and 3 of 4 individual siRNAs (see Specifications tab) Sequence information provided with siRNA purchase A two-stranded mechanism requires a two-stranded solution Dharmacon scientists and collaborators demonstrated in 2006 (see Reference 1) that siRNA off-targets are mediated by antisense seed-region interactions, initiating the development of a dual-strand modification pattern: Sense strand is modified to prevent interaction with RISC and favor antisense strand uptake Antisense strand seed region is modified to destabilize off-target activity and enhance target specificity Seed-region analysis on siRNA designs reduces miRNA-induced off-targets A landmark publication (see Reference 2) from the Dharmacon research group was the first to experimentally demonstrate the key role of the seed region in mediating off-targets. A subsequent 2008 paper (see Reference 3) showed the importance of seed frequency in the 3'UTR as in indicator of its likelihood to cause off-targets. These principles were subsequently applied to our siRNA designs to improve specificity: Design filters eliminate common seed regions likely to cause miRNA-like off-targets Seed frequency analysis for siRNA designs minimize off-target effects Available Product Formats SMARTpool: A mixture of 4 siRNA provided as a single reagent; providing advantages in both potency and specificity. siGENOME and ON-TARGETplus guaranteed to silence by 75% or better (see Specifications). Set of 4: A convenient option for purchasing aliquots of all 4 individual siRNAs targeting a single gene. Three of four siGENOME and ON-TARGETplus siRNAs are guaranteed to silence by 75% or better (see Specifications). Set of 4 Upgrade: Discounted price on the Set of 4 based on a concurrent or prior purchase of the SMARTpool reagent for the same gene. Individual siRNAs: Select 1, 2, or 3 individual siRNAs per gene. Minimum purchase of 4 at the 2 nmol size. |
Caracteristicas | siRNA designed and modified for greater specificity |
Marca | HORIZON |
Recomendaciones
-
Reactivos Transfección -DharmaFECT 1 Transfection Reagent573,36 € sin ivaPara ver tus precios y comprar inicia sesión
-
Librería Silenciamiento Génico -ON-TARGETplus siRNA Library - Ubiquitin Conjugation Subset 2 - Set of 4 - Human3.975,65 € sin ivaPara ver tus precios y comprar inicia sesión
-
Controles Silenciamiento Génico -SMARTvector Inducible Non-targeting mEF1a-TurboRFP Glycerol 7463,06 € sin ivaPara ver tus precios y comprar inicia sesión
-
Librería Silenciamiento Génico -SMARTvector Transcription Factors Lentiviral shRNA Pooled Library hCMV - Mouse9.084,48 € sin ivaPara ver tus precios y comprar inicia sesión
-
Librería Expresión Génica -hORFeome v8.1 Ion Channels4.013,89 € sin ivaPara ver tus precios y comprar inicia sesión
-
Control positivo, sgRNA lnetiviral de ratón, Edit-R Mouse All-in-one Lentiviral sgRNA421,89 € sin ivaPara ver tus precios y comprar inicia sesión
-
Librería Silenciamiento Génico -ON-TARGETplus siRNA Library - Ubiquitin Conjugation Subset 1 - SMARTpool - Mouse4.253,59 € sin ivaPara ver tus precios y comprar inicia sesión
-
Controles Silenciamiento Génico -SMARTvector Non-targeting Control mEF1a-TurboRFP UHT 122.868,95 € sin ivaPara ver tus precios y comprar inicia sesión
-
Librería Silenciamiento Génico -SMARTvector Inducible Protein Kinase Lentiviral shRNA Pooled Library PGK-GFP - Human10.225,65 € sin ivaPara ver tus precios y comprar inicia sesión
-
Librería Expresión Génica -MGC Fully Sequenced Human cDNA Set Growth Factor (glycerol stock)3.128,59 € sin ivaPara ver tus precios y comprar inicia sesión
-
Controles Silenciamiento Génico -SMARTvector GAPD mEF1a Control UHT -Rat2.868,95 € sin ivaPara ver tus precios y comprar inicia sesión
-
Reactivos Silenciamiento Génico - Accell siRNA Reagents - Human0,00 € sin ivaPara ver tus precios y comprar inicia sesión
-
Controles Silenciamiento Génico -SMARTvector Inducible Non-targeting mEF1a-TurboRFP Control Particles 5830,71 € sin ivaPara ver tus precios y comprar inicia sesión
-
Librería Silenciamiento Génico -SMARTvector Transcription Factors Lentiviral shRNA Pooled Library mEF1a-GFP - Human9.084,48 € sin ivaPara ver tus precios y comprar inicia sesión
-
Reactivos Silenciamiento Génico -ON-TARGETplus RTF - Phosphatases - black plates - Human6.903,59 € sin ivaPara ver tus precios y comprar inicia sesión
-
Controles Silenciamiento Génico -SMARTvector GAPD hEF1a-TurboGFP Control Particles - Human UHT - Human2.868,95 € sin ivaPara ver tus precios y comprar inicia sesión
-
Reactivos Silenciamiento Génico -siSTABLE GAPD siRNA - Mouse652,48 € sin ivaPara ver tus precios y comprar inicia sesión
-
Reactivos Silenciamiento Génico -Set of 3 SMARTvector Inducible LNC shRNA 100 µL - Rat2.276,30 € sin ivaPara ver tus precios y comprar inicia sesión
-
Controles Edición Génica -Edit-R Ppib Synthetic crRNA Control - Mouse156,89 € sin ivaPara ver tus precios y comprar inicia sesión
-
Librería Silenciamiento Génico -ON-TARGETplus siRNA Library - DNA Damage Response - Set of 4 - Human13.734,48 € sin ivaPara ver tus precios y comprar inicia sesión