Estándar de referencia estructural multiplex (formato FFPE) 50ng_µl, =400 ng_pieza

The Structural Multiplex Reference Standard covers a wide range of mutations in defined genomic context. This standard is designed to challenge your molecular and bioinformatics workflow by providing validated copy number variants/ amplifications, translocations and large insertions/deletions. Additionally, you may examine the genomic context of variants within regions of specific GC-content (high vs. low). The Structural Multiplex FFPE DNA Reference Standard includes 9 digital PCR-validated variants with allelic frequencies ranging from 3.5% to 9.7% and CNVs at 4.5x and 8.5x amplification.

Highlight features of this control material include RET and ROS1 fusion variants, MYC-N and MET focal amplifications and a BRCA2 variant.

The Structural Multiplex Reference Standard is also available in high molecular weight gDNA (HD753) and cfDNA (HD786) format.

Technical Data

• Genes Covered AKT1, BRAF, BRCA2, EGFR, FBXW7, FLT3, GNA11, KRAS, MET, MYC-N, NOTCH1, PIK3CA, RET, ROS1
• Fixation Method 4%
• Formalin Section Size 15 µm
• Cell Density 3 x 108 cells per block.
• Approx. 3.5 x 105 cells per section
• Expected DNA Yield ≥ 400 ng DNA per section using Promega Maxwell LEV Plus FFPE DNA Extraction kit
• Product information- please check in the Horizon webpage https://www.horizondiscovery.com